The Lady Bears (27-0, 14-0 Big 12) jumped out to a 9-0 start, but Monique Smalls three started an 11-0 Tech run to give Tech its first lead of the game.
After another pair of lead changes, the Lady Raiders took over for good for the rest of the first half, leading by as much as nine before going into the break with a 35-30 lead.
But Baylor came out strong in the second half, regaining the lead at 42-41 and it never gave it back up.
Brittney Griner had a game high 18 points, while Smalls led all Tech scorers with 13 points. Kierra Mallard was the only other Lady Raider (17-9, 5-9) in double digit points with 10 off the bench.
The win locked up at least a share of the Big 12 title for Baylor while dropping Tech to 5-9 in conference play.
Tech returns home Tuesday to take on Kansas (17-9, 6-8).